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Dr. B. Singaravelan

Project Faculty
UGC-Networking Resource Centre in Biological Sciences
School of Biological Sciences
Madurai Kamaraj University
Madurai - 625 021, India
Mobile: 8012633278,E mail: microgeneticsings@gmail.com

Areas of Research Interest:

Genetic regulation of Mutagenesis in Escherichia coli, Genetic Regulation of Proteases, Molecular and Genetic Analysis of Suppression, Bacterial Motility, Genetic Code Reassignments, Genetics of Incompatibility suppressors, Microbial Pathogenesis, Finding out the Molecular and Genetic nature of resistance of clinically important antibiotics, Development of Industrially / Agriculturally important microorganisms, Metagenomics and Microbial Bioremediation.

Papers Presented in Conferences:-
 
1. In vivo suppression of opal nonsense codon by ochre suppressor. K.Shanmugapriya, B.Singaravelan and M.Hussain Munavar. Poster presented at the Science Day & Aqua-Terr Annual Conference on Genomic Sciences” held at School of Biological Sciences, MKU (UPE) on February 28, 2011.

2. Cloning of supE44, an amber suppressor and its multicopy effect in Escherichia coli. Ajit Prakash., B.Singaravelan and M.Hussain Munavar. Poster presented at the Science Day & Aqua-Terr Annual Conference on Genomic Sciences” held at School of Biological Sciences, MKU (UPE) on February 28, 2011.

3. Misreading of opal stop codon by selenocysteine tRNA in Escherichia coli. Anirban Pradhan., B.Singaravelan and M.Hussain Munavar. Poster presented at the Science Day & Aqua-Terr Annual Conference on Genomic Sciences” held at School of Biological Sciences, MKU (UPE) on February 28, 2011.

4. Isolation and partial characterization of spontaneous aminoglycoside antibiotic resistant mutants of Escherichia coli. S.Vinodha., B.Singaravelan and M.Hussain Munavar. Poster presented at the Science Day & Aqua-Terr Annual Conference on Genomic Sciences” held at School of Biological Sciences, MKU (UPE) on February 28, 2011.

5. Molecular and genetic characterisation of a novel rpsD allele in Escherichia coli. Aravind Natarajan., B.Singaravelan and M. Hussain Munavar “Paper presented at the Science Day & Aqua-Terr Annual Conference on Genomic Sciences” held at School of Biological Sciences, MKU (UPE) on February 28, 2011.

6. Genetic analysis of spontaneous tobramycin resistant mutants of Escherichia coli. S.Vinodha., R.Shanmughapriya., B.Singaravelan and M.Hussain Munavar. Poster presented at the “International Conference on Genomic Sciences - Recent Trends (ICGS-2010)” held at School of Biological Sciences, Madurai Kamaraj University on November 12-14, 2010.

7. Level of loss of lon-uvrD incompatibility in phenotypically Alp+/- strains of Escherichia coli and its implications in vivo turnover of sulA. N.Arul Muthu Kumaran, R.Janakiram, B.Singaravelan and M.Hussain Munavar. Poster presented at the “International Conference on Genomic Sciences - Recent Trends (ICGS-2010)” held at School of Biological Sciences, Madurai Kamaraj University on November 12-14, 2010.

8. Analysis of sequence change due to thr1 lesion of Escherichia coli strain AB1157: Evidence that thr1 defines an amber allele of thrB and rpsL31 anti-suppresses the supE44 effect. B.Singaravelan and M.Hussain Munavar. Poster presented at the “International Conference on Genomic Sciences - Recent Trends (ICGS-2010)” held at School of Biological Sciences, Madurai Kamaraj University on November 12-14, 2010.

9. Loss of lon-uvrD Incompatibility in lus mutant of E.coli: lus is tightly linked to uvrD. Sutharsan.G., Singaravelan.B and Hussain Munavar.M “Paper presented at 2nd Indian Youth Science Congress conducted jointly by SRM University, Chennai and MS Swaminathan Research Foundation on June 26 to 28, 2010.

10. Molecular genetic analysis of supE effect modulators in Escherichia coli. B.R.Roshini., B.Singaravelan and M.Hussain Munavar. Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 06, 2010.

11. Further studies on lon-uvrD incompatibility in Escherichia coli and their implication. Sutharsan.G., Singaravelan.B and Hussain Munavar.M. Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 06, 2010.

12. Characterization of mutations that counteract rpsL31 effect on supE44 in Escherichia coli: Do they affect ribosomal components? K.R. Vaijayanthi., B.Singaravelan and M. Hussain Munavar “Paper presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 06, 2010.

13. Isolation and partial characterization of a mutation (lus) capable of suppressing lon uvrD incompatibility in Escherichia coli. Sutharsan.G., Singaravelan.B and Hussain Munavar.M “Paper presented at National Symposium on Recent Advances in Biotechnology” conducted by Anna University, Tiruchirappalli on January 23-24, 2010.

14. Nucleotide sequence of glnVX region of Escherichia coli CSH34. Evidence for presence of an amber suppressor in glnX and its ability to suppress ochre also. B.Singaravelan and M.Hussain Munavar. “Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 14, 2009.

15. Lon suppression in Escherichia coli. Elevated suppression by lsp in combination with ssrA::cat allele. Ajitha Gomathi., B.Singaravelan and M.Hussain Munavar. “Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 14, 2009.

16. Lon-UvrD and Lon-PriA incompatibility suppression by dnaJ and ssrA mutations in Escherichia coli. R.Janakiram., B.Singaravelan., N.Arul Muthu Kumaran and M.Hussain Munavar. “Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 14, 2009.

17. Evidence for the involvement of N-Terminal portion of DnaK in eliciting Alp+ phenotype in Escherichia coli, Neha Puri., B.Singaravelan and Munavar, M.H. “Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 29, 2008.

18. Molecular genetic characterization of a Promoter-lacZ+ fusion regulated by Escherichia coli Lon protease. R. Shanmughapriya., B.Singaravelan and Munavar, M.H. “Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 29, 2008.

19. Evaluating the extent of suppression of lon-uvrD in compatibility in phenotypically Alp+ strains of Escherichia coli. M. Meenakshi., Arul Muthu Kumaran, N., Singaravelan, B. and Munavar, M.H. “Poster Presented at the Science Day & Aqua-Terr Annual Conference” held at School of Biological Sciences, MKU (UPE) on March 29, 2008.

20. Studies on suppression of lon –uvrD incompatibility and modulation of cps genes in Escherichia coli. N.Arul Muthu Kumaran, B.Singaravelan and M.Hussain Munavar. Poster presented at the Science Day &Aqua-Terr Annual Conference held at School of Biological Sciences, Madurai Kamaraj University (10th March 2007).

21. Isolation and partial characterization of Lon-dependent promoter-lacZ+ fusions in Escherichia coli. Shirin Ghodke, B.Singaravelan and M.Hussain Munavar. Poster presented at the Science Day &Aqua-Terr Annual Conference held at School of Biological Sciences, Madurai Kamaraj University (10th March 2007).

 

Research Papers Published:

1. Evidence that supE44 Mutation of Escherichia coli is an Amber Suppressor Allele of glnX and that it also Suppresses Ochre and Opal Nonsense Mutations. Singaravelan.B, Roshini, B.R. and M.Hussain Munavar. (Journal of Bacteriology, November 2010, p. 6039-6044, Vol. 192, No. 22) (doi:10.1128/JB.00474-10)

Comments:
The article (Journal of Bacteriology, November 2010, p. 6039-6044, Vol. 192, No. 22) is commented on Proteomics Weekly December 13, 2010. Scientists at Madurai Kamaraj University, Department of Molecular Biology release new data on Escherichia.

 

Gene Sequences published:

1. Singaravelan,B., Roshini,B.R. and Hussain Munavar,M (30-NOV-2010). DEFINITION: Escherichia coli strain CSH34 tRNA-Met, tRNA-Leu, tRNA-Gln, tRNA-Met, and tRNA-Gln genes, complete sequence. GenBank ACCESSION: HQ111556.1.