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Department:  Dept. of Genetics, Centre for Excellence in Genomic Sciences
E-mail ids: ggopalan85@hotmail.com; g.gopalan@nrcbsmku.org
Phone numbers: +91 9600428129

A brief write up about the research work:
Aurora kinases evolve as a new family of mitotic, centrosome and microtubule-associated kinases that regulate the structure and function of centrosomes and mitotic spindle.  One of its members, Aurora-A kinase, has been shown to play an oncogenic role in cancer. As an important regulator of cell division with its oncogenic properties, Aurora-A is a potential target for inhibitory molecules that could inhibit cell cycle progression and thus could be useful as cancer therapeutic.  In recent years, Aurora-A expression has been emerging as a means to predict the outcome of the disease and Aurora-A as a promising anti-cancer target.  Our research activities are directed towards understanding the negative regulation of Aurora-A kinase as well as Aurora-A-linked signaling pathways contributing towards tumorigenesis and chemoresistance. 

 Honors and Recognitions:
1987-1989       Humboldt Fellow, Alexander von Humboldt Foundation, FRG.
        2000       Young Investigator Scholar Award, American Association for Cancer
        2010 –     Invited member of the Review Editorial Board of Frontiers in vascular

 Area of Research:    Cancer cell signaling, Epigenomics

Ongoing Research projects:
Title:        “Expression profiling of miRNAs and their regulatory circuit in A2M induced 
                hypertrophy and heart failure”
Agency:     Department of Biotechnology
Amount:    INR  35,35,000
Role:         CoPI


 Recent Publications:
1.   Dullo I, Gopalan, G, Melino G and Sabapathy K (2010). "The anti-apoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway". Proc. Natl. Acad. Sci. USA. 107:4902-07.
2.  Heng HL, Yansong Z and Gopalan, G. (2008) Dowregulation of Aurora-A kinase overrides estrogen-induced growth and chemoresistance in breast cancer cells. Endocrine Related cancers 15: 765-775.
3.  Lim SK and Gopalan, G(2007) Antizyme1 mediates AURKAIP1-dependent degradation  of Aurora-A. Oncogene 26:6593-603
4.  Lim SK and Gopalan, G (2007) Aurora-A kinase interacting protein (AURKAIP1) promotes  Aurora-A degradation through an alternative ubiquitin-independent   pathway.  Biochem J. 403:119-27.