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INVESTIGATOR'S PROFILE

 



Prof. G.S. SELVAM  

 

 

 

 

 

 

 

Professor & Head                                                                   

School of Biological Sciences,
Professor & Head
Dept of Biochemistry  

School of Biological Sciences
Madurai Kamaraj University

Madurai 625 021

RESEARCH AREAS :

  1. Development of transgenic Lactobacillus plantarum for therapeutic application
  2. Development of cardiovascular marker
  3. Identification of novel biomarker for oral cancer using saliva

CONTACT DETAILS:

Phone: 0452-2458213/2458223
Email: drselvamgsbiochem@yahoo.com

RESEARCH INTERESTS:

Development of transgenic Lactobacillus plantarum for therapeutic application:

The medical management of calcium oxalate recurrent stone patient is a difficult problem. Using genetically manipulated oxylate degrading bacterial species for medical diagnosis and treatment will be highly valuable in patient management. Our objective is focused on cloning and expression of oxalate degrading gene from Mesorhizobium sp. mku–E2 in a probiotic organism Lactobacillus plantarum for the therapeutic applications. 

Development of cardiovascular marker:

Identification of cardiovascular diseases using cardiac marker will help in better therapy and clinical management. Myocardial structure and signal transduction are now merging into a common field of research that will lead to a more complete understanding of the molecular mechanisms that underlie heart disease. Our specific objective is to study the relative participation of Notch signaling pathway in the development and progression of heart disease and signaling pathways that may mediate reprogramming of gene expression in animal model system.

Identification of novel biomarker for oral cancer using saliva:

Proteomic technologies will be applied to identify proteins in human whole saliva to develop saliva protein as biomarkers for human oral and systemic diseases. Currently, my lab is focused on development of oral cancer biomarker.

 

PUBLICATIONS

  1. Selvam GS, Varalakshmi P. (1989) Effect of different isomers of tartarate   on oxalate metabolism in hyper oxaluric rat. Medical Science research. 17: 685- 87. U.K
  2. Selvam GS, Varalakshmi P. (1990) Role of L (+) Tartarate in experimental tartaric acids on calcium oxalate urolithiassis, Medical Science Research 18: 345-348. U.K.
  3. Selvam GS, Varalakshmi P. (1990) In vitro studies on effect of tartaric acids on calcium oxalate urolithiassis, Arogya. Health Science Vol .XVI pp.33-42
  4. Selvam GS, Varalakshmi P.   Biochemical changes in kidneys of normal and stone forming rats with L(+)-tartrate.  Indian J Exp Biol. 1990 Nov;28(11):1046-9.
  5. Selvam GS, Varalakshmi P. (1991) Effect of L (+) tartarate on some biochemical and enzymatic parameters in normal and glycolate treated rats. Pharmacological Research 26: 385-393
  6. Selvam GS, Varalakshmi P. (1992) Changes in liver constituents in stone forming rats treated with L (+) Tartarate Ind.J.clin Biochemi, 6:39-45.
  7. Selvam GS, Subha K, Varalakshmi P. Effect of L(+)-tartrate on some biochemical and enzymatic parameters in normal and glycollate treated rats. Pharmacol Res. 1992 Dec; 26(4):385-94. 
  8.  A. Anitha, K. Sheeja and G. S. Selvam 1997. Restriction endonuclease analysis of mitochondrial DNA in two populations of Penaeus indicus H. Miline Edwards. Journal of Experimental biology 35, 948-955.    
  9. M.K. Suresh Kumar, G.S. Selvam and P.S. Jasmine (1998) Cadmium tolerance and metal accumulation by bacterial strain from industrial effluents. J.of. Scientific and Industrial Research 57:817-820.
  10. A. Nazeema, Sheji Mary and Selvam G.S. (1998) Isolation and characterization of oxalate degrading bacteria from marine and terrestrial environment of Cochin. J.of.Scientific and Industrial Research Vol 57:795-799
  11. S.Jayasree, G.S. Selvam and Sunil Thomas (2000). Development of an enzyme –   linked immunosorbent assay (ELISA) for agglutination, an antibacterial protein of the shrimap fenneropenaeus indicus, Journal of crustacean biology, 20(4) 621-627.
  12. M. K. Suresh Kumar, H.H.Krishnan and G.S. Selvam (2001). Cadmium Resistant   Bacteria Pseudomonas species located from Cochin environment. Ed .C.S.P Iyer Asia Research Publishers, In. New Delhi 298-304. 
  13. Andiappan Rathinavel, Perundurai Subramanian Dhandaphani, Ponnambalam  Annapoorani, Subbiah Ramasamy and Govindan Sadasivam Selvam.(2004) Cardiac isoform of alpha 2 macroglobulin(182 Kda protein) as a noval gnostic marker for cardiac diseases. European journal of Cardiovascular prevention and  Rehabilitation.2005, Vol 12 No 6.
  14. Chelliah Edward Raja, Kolandaswamy Anbazhagan and Govindan Sadasivam Selvam.  Isolation and characterization of metal resistant Psedomonas aeruginosa strain. World journal of Microbiology and Biotechnology – 2005 
  15. Rathinavel, P.S. Dhandapani, P. Annaporani, S. Ramaswamy and G. S. Selvam 2005. Cardiac isoform of alpha 2 macroglobulin (182kda protein) as a diagnostic marker for cardiac disease. European Journal of Cardiovascular prevention and Rehabilitation 12.
  16. M. Viswanathan, Pravin. R. Solomon, N. Tsuchida, G. S. Selvam and  G. Shanmugam 2006. Hypermethylation analysis of E. Cadtherin and hMLH genes associated with Indian breast carcinoma. Indian Journal of Experimental Biology 44, 1196-1198.
  17. P. Annaporani, P.S. Dhandapani, S. Sakthivel, S. Ramaswamy and G.S. Selvam 2006. Cardiac isoform alpha 2 macroglobulin as a diagnostic marker for myocardial infarction diabetic patients. Atherosclerosis 186, 173-176.
  18. B. Tom Paul, A. Patel, G.S. Selvam, S. Mishra and R. Murugesan 2006 Photodynamic action of C-phycocyanins obtained from marine and fresh water cyanobacterial cultures: A comparative study using EPR spin trapping technique. Free Radical Research – Free Radic Res. 2006 Aug.40(8):821-5.
  19. S. Ramaswamy, A. Rathinavel, P.S. Dhandapani and G. S. Selvam 2006. Cardiac      isoform of alpha 2 macroglobulin (CA2M) an early diagnostic marker for cardiac manifestations in AIDS patients. AIDS. 2006 Oct 3.20(15):1979-81.
  20. Subbiah Ramasamy, Pitchai Balakumar, Manjeet Singh, Andiappan Rathinavel, Koteshwara Ananthamurthy, Tharmarajan Ramprasath and Govindan Sadasivam Selvam. Functional Characterization of Cardiac isoform of Alpha 2 Macroglobulin (CA2M): Identification of Non-Hypertrophic Domain. The Cardiology 3 (2): 20-23, 2007.
  21.  Dhandapany PS, Sadayappan S, Vanniarajan A, Karthikeyan B, Nagaraj C, Gowrishankar K, Selvam GS, Singh L, Thangaraj K.(2007) Novel mitochondrial DNA mutations implicated in Noonan syndrome. Int J Cardiol. Aug 21:120(2):284-5.
  22. Solomon PR, Selvam GS, Shanmugam G (2008). Promoter hypermethylation analysis in myeloplastic syndromes: Diagnostic & prognostic implications. Indian Journal of Medical Research. 127, 52-57.
  23. Solomon PR, Selvam GS, Shanmugam G. (2008). Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians. Oral Dis. Feb 10.
  24. nbazhagan kolandasamy, Leema George, Selvam GS (2009) Heterologous Expression of Oxalate decarboxylase in Lactobacillus
    plantarumNC8. Current Microbiology 58: 117-121.
  25. nbazhagan K, Sampathkumar K, Ramakrishnan M, Gomathi P, Gomathi S, Selvam GS (2009) Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients.Clin Chim Acta 406: 108-12.
  26. dward Raja C, Selvam GS (2009) Plasmid profile and curing analysis of Pseudomonas aeruginosa as metal resistant. Int. J.
    Environ Sci Tech.6: 259-266.
  27. aul BT, Babu MS, Santhoshkumar TR, Karunagaran D, SelvamGS, Brown K, Woo T, Sharma S, Naicker S, Murugesan R (2009)
    Biophysical evaluation of two red-shifted hypocrellin B derivatives as novel PDT agents J Photochem Photobiol B 94: 38-44.