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INVESTIGATOR'S PROFILE

 

Dr. J. Sridhar

 

 

 

 


 

Project Faculty
School of Biological Sciences
Madurai Kamaraj University
Madurai - 625 021, India
Tel : +91 452 2458212
Fax: +91 452 2459873
Mobile: +919751648767
E mail: srimicro2002@gmail.com; jsridhar@nrcbsmku.org

RESEARCH INTERESTS

  1. Microbial genomics of non-coding small RNAs
  2. RNA-SEQ data analysis and mapping for sRNA identification & characterizations
  3. DNA repeat based polymorphisms in Salmonella spp
  4. Prophages mediated genome evolution in Salmonella spp
  5. CRISPR Biology

Research Experiences

  • Faculty in the School of Biological Sciences from February 2011 onwards.
  • Post Doctoral Scientist, Austrian Academy of Sciences, Austria (2010-2011)
  • Visiting Doctoral Fellow, Max Planck Institute of Infection Biology, Berlin, Germany (2009 - 2010)
  • Visiting Doctoral Fellow, Department of III, University of Leicester, United Kingdom 12 months (2007-2009)
  • Research Fellow, School of Biotechnology, MKU, Madurai, India from 2004-2009

HONOURS AND AWARDS

  • ICMR travel grant – Govt. of India tenable at Malaysia (2011)
  • Post Doctoral Fellowship - AAS, Austria (2010-2011).
  • Visiting Doctoral Fellowship - MPIIB, Germany (2009-2010)
  • UGC-Commonwealth Split-site Doctoral award - CSC, United Kingdom (2007-2009).
  • DST-ITS travel grant – Govt. of India tenable at Singapore (2009).
  • Recipient, Junior and Senior Research Fellowship – DBT Govt. of India (2004–2009).

MEMBERSHIP IN SCIENTIFIC SOCIETIES

  • Life member – Biotech Research Society of India (BRSI)
  • Member – International Society for Computational Biology (ISCB)
  • Member - APBionet
  • Member – Society of Biological Chemists in India (SBCI)

International Research Trainings and Participations:

  • Attended an international Transcriptomics workshop (Jan 28-30, 2008) organized by the European Bioinformatics Instittute (part of EMBL), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Participated in the master level training (March 21, 2009) organized by EMBL-EBI, Hinxton, Cambridge, United Kingdom.
  • Participated in the Satellite meetings and SIGS at InCoB 2009 (September 7-11, 2009) organized by Asia Pacific Bioinformatics Network (APBioNet) in Singapore.
  • Attended the INCOB 2011 conference organized by ISCB-APBioNet in Kuala Lumpur, Malaysia (November 30-December 2, 2011).

Presentations in International Conferences:

  • Sridhar, J. and Gunasekaran, P. (2011). Analysis of genome sequences for Fur interacting sRNAs and coding genes possibly involving in iron metabolism, presented in InCoB 2011 held in at Kuala Lumpur, Malaysia.
  • Sridhar, J. and Gunasekaran, P. (2011). Computational Genomics to diagnostics: Detection of Salmonella spp. from human adapted serovars Typhi and Paratyphi A, presented in ISB 2011 held in at NIT, Calicut.
  • Sridhar, J, Sowmya, G, Sekar, K and Rafi, Z.A. (2009). “PsRNA: A COMPUTING ENGINE FOR THE COMPARATIVE IDENTIFICATION OF PUTATIVE SMALL RNA LOCATIONS WITHIN INTERGENIC REGIONS” Presented at INCOB 2009, held at Singapore, September 7-11, 2009.
  • Sridhar, J and Rafi, Z.A. (2006a). “Enterobacteriacae: A comparative genomics of small RNA” at the Indo-French Bioinformatics Meeting (IFBM 2006), National Centre for Biological Sciences, Bangalore, INDIA.
  • Mahalingaraja, U. Sridhar, J and Rafi, Z.A. (2006b). “Small RNA identification in Bacillaceae and Lactobacillaceae using comparative genomics: SRP and RNaseP” at the Indo-French Bioinformatics Meeting (IFBM-2006), National Center for Biological Sciences, Bangalore, INDIA.
  • Sridhar, J and Rafi, Z.A. (2006c). “Identification of small RNA associated genomic islands” presented at INCOB 2006 New Delhi on December 18-20, 2006.

Publications:

  • Sridhar, J and Rafi, Z.A. (2007a). Small RNA identification in Enteroabcteriaceae using synteny and genomic backbone retention. OMICS Vol. 11: 74-99.
  • Sridhar, J and Rafi, Z.A. (2007b). Identification of novel genomic islands associated with small RNAs. In Silico Biol. Vol. 7:601-611.
  • Sridhar, J and Rafi, Z.A. (2008). Functional annotations in bacterial genomes based on small RNA signatures. Bioinformation Vol. 2:284-295.
  • Sridhar, J. Sekar, K and Rafi Z. A. (2009a). CsrA interacting small RNAs in Haemophilus spp genomes: A theoretical analysis. Arch Microbiol Vol. 191: 451-459.
  • Sridhar, J. Sathesh Kumar, S and Rafi, Z.A. (2009b). Small RNA identification in Enteroabcteriaceae using synteny and genomic backbone retention II. OMICS Vol. 13, 261-284.
  • Sathesh-Kumar, S. Sridhar, J and Rafi, Z.A. (2009c). sRNAbase: A web resource for small RNAs in Enterobacteriaceae. In Silico Biol. Vol. 9: 0035.
  • Sridhar, J. Sowmiya, G. Sekar, K and Rafi, Z.A. (2010a). PsRNA: A COMPUTING ENGINE FOR THE COMPARATIVE IDENTIFICATION OF PUTATIVE SMALL RNA LOCATIONS WITHIN INTERGENIC REGIONS. Genomics, Proteomics and Bioinformatics. Vol. 8: 127-134.
  • Sridhar, J and Kavitha, K. (2010b). sRNA associated Genomic Islands in Salmonella spp. Proceedings of International Symposium on Bio-computing-Feb.2010 ACM Digital Library Article No. 29 ISBN:978-1-60558-722-6
  • Bindal, A.K. Sabarinathan, R. Sridhar, J. Sherlin, D and Sekar, K. (2010c). An algorithm to find all identical motifs in multiple biological sequences. PRIB 2010, LNBI 6282, pp. 132–143, 2010.
  • Sridhar, J. Narmada, S. Sabarinathan, R. Rieck, B. Ou, H-Y. Deng, Z. Sekar, K. Rafi, Z.A and Rajakumar, K (2010d). sRNAscanner: a transcriptional signal-based bio-computational method for the detection of non-coding small RNAs in bacterial genomes. PLoS ONE (http://dx.plos.org/10.1371/journal.pone.0011970).
  • Sridhar, J. (2010). Current trends and the future of prokaryotic sRNA identification. Biotech International pp 10-11.
  • Sridhar, J and Gunasekaran, P (2011b). Computational genomics to diagnostics: Detection of Salmonella spp and human adapted serovars Typhi and Paratyphi ‘A’. Proceedings of the Indo-US workshop on Biocomputing-2011, pp 130-135.
  • Sujatha, K., Mahalakshmi, A., Sridhar, J. and Gunasekaran, P (2011c). Pseudomonas sp. as a source of Medium Chain Length Polyhydroxyalkanoates- (mcl-PHAs) for Controlled Drug delivery – A Perspective, International Journal of Microbiology (Accepted).
  • Ganesh Babu, M.M., Sridhar, J. and Gunasekaran, P (2011d). Global transcriptome analysis of Bacillus cereus ATCC 14579 in response to silver nitrate stress. J Nanobiotechnology, 9: 49.
  • Nitin, P., Sridhar, J., et al., (2012) Computational Studies on molecular interactions of 6-thioguanosine analogs with Anthrax Toxin Receptor 1. Interdisciplinary Sciences: Computational Life Sciences, 4:1-7.
  • Vinoth, D., Sridhar, J., et al., (2012) Modeling and structural analysis of cellulases using Clostridium thermocellum as template, Bioinformation, 8: 22.
  • Sridhar, J., Sabarinathan, R., Gunasekaran, P. and Sekar, Kanagaraj. (2012).Comparative genomics reveals 'novel' Fur regulated sRNAs and coding genes in diverse proteobacteria. GENE (Accepted).
  • Sridhar, J., Gunasekaran, P. (2012). Computational prediction of small RNA in bacteria. Bioinformatics and Biology insights (Accepted)
  • Assraf, S.S., Mahalakshmi, A., Sridhar, J. and Gunasekaran, P. (2013). Computational and functional characterization beta-lactum resistance in Zymomonas mobilis. Biologia (Accepted).

Book Chapters:

  • A book chapter on “The Small RNAs of Salmonella” by Jayavel Sridhar, Kai Papenfort and Jorg Vogel, in “Salmonella: From Genome to Function” (2010) edited by Steffen Porwolik. Publisher: Horizon Press, USA ISBN: 978-1-904455-73-8.
  • Laboratory Manual on “Comparative Genomics and Proteomics in Drug Discovery”  by P. Gunasekaran, R. Murugesan, J. Sridhar and A. Mahalakshmi published by UGC-NRCBS, MKU (2011).
  • Laboratory Manual on “Computational genomics and its applications” by P. Gunasekaran, R. Murugesan, J. Sridhar and A. Mahalakshmi published by UGC-NRCBS, MKU (2011).

ONGOING RESEARCH PROJECTS

  • “Construction of computational platform for the identification of non-coding small RNAs and small ORFs in bacteria” funded by DBT (2012-2015) (PI).
  • “Analysis and identification of prophage mediated genome evolution in Salmonella spp.” Approved for funding from UGC (2012-2015) (PI).
  • “Identification of micro RNAs of the Potyviridae family” funded by CSIR (2012-2015) (Co-I).
  • “Genomic repeats and polymorphisms in the virulent determinants of Salmonella spp” proposal submitted to DST for financial support (PI).