M.Sc Genomics

M.Sc Genomics

 

Madurai Kamaraj University

(University with Potential for Excellence)

M.Sc. - Genomics

(Course offered by

School of Biological Sciences,

Madurai Kamaraj University)

Regulations

 

VISION
School of Biological Sciences (SBS) of Madurai Kamaraj University is a UGC recognized Centre with the potential for Excellence in Genomic Sciences with the demonstrated research accomplishments in different aspects of modern life sciences including Genomics. One of the visions of the SBS is to train life science students in the area of Genomics with the world-class theoretical and applied knowledge to enable them to solve any biological and biomedical problems with Genomics Technology. The trained manpower is expected to be the young talent pool of the country to provide genomic solutions to the biological and biomedical problems of the globe at different capacities.

MISSION
School of Biological Sciences of Madurai Kamaraj University has significantly contributed in the area of Genomics and Life Sciences. With the established ecosystem of genomics and life-science research with muti-parallel genomics research investigations and the state-of-the-art infrastructure, it is designed to train the M.Sc students for academic excellence in Genomics. Teaching and training ad-midst of the ongoing world-class research investigation is the mode of 4 training rendered to the students. Maintaining the track-records and the vibrant academic atmosphere of the School with various learning, research and extension programs are expected to keep-up the momentum very high and to set the goals of the students very high in global contexts.

COURSE FEATURES

The course is organized on a semester basis with a total of four semesters. In the first three semesters the students will be doing three theories and one practical core paper. Fourth semester is for project work and research methodology paper. For every semester the students must choose one elective and one soft skill paper on their choice. A list of subjects, their codes, credits and marks of evaluation are compiled in the table.

PREAMBLE

Genomics is an important emerging discipline in Biological, Biomedical, Industrial, and Agricultural Sciences with the genome-wide information of the genetic, epigenetic, and genomic processes, which in turn form the base for the phenotype of the living system.  Genomics also involves a series of unbiased assays and approaches to understand the complexity and diversity of Genomes. Genomic approaches provide solutions in biomedical research by creating possibilities for new therapies for genetic and pathogen borne diseases. Because of its immediate and considerable impact on global health, there is a demand for highly qualified and trained human resources in the field of genomics.

ABOUT M.Sc. GENOMICS PROGRAMME:

University Grants Commission recognized the School of Biological Sciences, Madurai Kamaraj University as Centre of Potential for Excellence in Genomic Sciences in 2002, to initiate research and teaching activities in the area of Genomic sciences.  M.Sc. Genomics course is offered since 2002 by the School of Biological Sciences under the auspices of the Centre of Potential for Excellence in Genomic Sciences. Students with high academic standards are selected through the National Level Entrance Test conducted by the University. The course is offered under Choice Based Credit System (CBCS) according to UGC regulations. Department of Biotechnology (DBT) also supported to establish the laboratory, equipment and learning resources for the M.Sc. Genomics program.

It is worth mentioning that the outgoing students of  M.Sc., Genomics are highly successful in finding the right opportunities. More than 90% of the M. Sc., Genomics students pursue their higher education through Ph. D. Of these, 30% of students go abroad for Ph.D. and the remaining get into the good institutes in India. Out 250 students completed the M.Sc Genomics program, about 165 of them have completed their Ph.D. from the leading Institutions in India and abroad.

The School of Biological Sciences has State-of-the-art laboratory facilities, excellent computer lab, Wi-Fi network connectivity, and library facility with e-journals/books.  The high throughput instrumentation facilities of the school include Automated DNA sequences, Real-Time PCR machine, Robotic Liquid Handling systems, Flow Cytometer, Microarray, High Content Screening System, Cell culture Labs, Next Generation Sequencer, LC-MS/MS, etc.

REGULATIONS

  1. ELIGIBILITY FOR ADMISSION AND MODE OF SELECTION
  2. a. A Bachelor’s degree in any branch of Life Sciences (Botany, Zoology, Microbiology, Biochemistry, Biotechnology, Genetics or Equivalent, Physical and Chemical Sciences (Physics and Chemistry), Medicine, Veterinary and Agriculture from any recognized Indian or Foreign University. Students with B. Tech., Degrees in Biotechnology, Computer Science, Information Technology and Bioinformatics with Biology at +2 level are also eligible. Students with high academic credentials in degree will be selected through a national level entrance test. 

    B. To have national representation, 40% of the seats are reserved for students from other than Tamilnadu, and the remaining 60% seats are filled following the Tamilnadu reservation policy.

  3. C. Total number of seats: 20
     Other state -8
    Tamilnadu -12


    1. PROCESSING OF APPLICATION:

    The pattern of the entrance test available on our website.  The short-listed candidates will be called for an interview/ Seminar / discussion held at Madurai Kamaraj University.

    1. DURATION OF THE COURSE

    The students will undergo the prescribed course of study for a period of not less than two academic years (four semesters)

    1. Medium of Instruction: English
    1. Subjects of study &Scheme of Examinations: As given in Appendix A
    2. Eligibility for the degree: Candidate will be eligible, provided he/she completes the course and pass in the prescribed examinations.
    3. GUIDELINES REGARDING PASS MINIMUM:

    To get a pass, should fulfill the following conditions:

      Theory:
  4. 50% of the aggregate (External + Internal).
  5. No separate pass minimum of internal
  6. 34 marks out of 75 is the pass minimum for the External.
    1. Practical’s:

     

    1. 50% of the aggregate (External + Internal)
    2. No separate pass minimum for the internal
    3. 27 marks out of 60 is the pass minimum for the External.
    1. Project:
    1. 50% of the aggregate (project evaluation + Viva-voce)
    2. No separate pass minimum for the viva-voce
    3. 34 marks out of 75 is the pass minimum for the project evaluation.
    4. QUESTION PAPER PATTERN

        The existing pattern of question paper will be as follows:

     Time: 3 hours                                                           Max Marks: 75

     Section A: (10 x 1 =10)

     Question No 1 to 10

    1. Two questions from each unit.
    2. Four choices in each question.
    3. Answer all questions. Choose the right answer.

    Section B:  (5 x 7= 35 marks)

    Answer all questions - Either OR types

    Answer not exceeding two pages.

    (One question from each unit)

    Question Nos.

    11a or 11b

    12a or 12b

    13a or 13b

    14a or 14b

    15a or 15b

     

    Section C: (3 x 10 = 30 marks)

     Answers not exceeding four pages

    Answer any THREE out of Five (one question from each unit)

                     Question Nos.- 16-20

    The pattern for internal valuation may be:

    1. Two internal tests of 15 marks each: Average     = 15 marks
    2. Group discussion/ Seminar/ Quiz   = 05 marks
    3. Two assignments: %marks each:          Average   = 05 marks

     

    1. c) Practical Exams: External (MAX: 60 Marks)

     

    One Major Experiment                                             = 20 marks

    One Minor Experiment                                             = 10 marks

    Two spotters                                                             = 05 marks

    Record Book                                                              = 05 marks

    Viva Voce                                                                   = 20 marks

    The pattern for internal valuation for 40 marks may be:

    1. d) Two internal tests of 25 marks each: average = 25 marks
    2. e) Observation book = 10 marks
    3. f) One assignment = 05 marks

     

     

    1. d) Project evaluation: (MAX 100 Marks)

    External max: 75

    Dissertation work                                                     = 60 marks

    Presentation and viva                                                           = 15 marks

    Internal max: 25 marks                                        = (decided by the guide)

     

    1. Restriction to complete the course:

    In order to qualify for the degree, a candidate should complete all the prescribed Theory/Project examinations and secure a minimum of 64 credits in the core examination, 16 credits in elective and 10 credits in SSS course within a minimum period of two years  and maximum period of five years counting from the date of admission to the course.

     

     

     

    • Declaration of result:

    A candidate should get a minimum of 64 credits in the core examination, 16 credits in elective and 10 credits in SSS course in aggregate should secure 90 credits to pass. On successful completion of the PG programme, a candidate will be declared to have passed the exam with class and grade points that is computed on the basis of cumulative weighted average marks obtained in percentage.

     

    • FEE STRUCTURE
    1. Tuition fees per year 4,200/-
    2. Lab fee 8,000/-
    3. Special fee per year 1,390/-  
    4. Other fees 100/-
    5. Computer / Internet 1,200
    6. CBCS Hand Book 100/-
    7. Alumni fees                                           500/-
    8. Students’ Aid Fund 10/-
    9. Caution Deposit (Refundable) 1,000/-
    10. Total 16,500/- per year   

     

    PROGRAM EDUCATIONAL OBJECTIVES (PEOs):

     

    School of Biological Sciences has significantly contributed to the research, development, and human resources development in the area of Genomics and Biological Sciences.  The objectives of the program are

     

    PEO1: to profoundly train the students in the field of Genomics with modern genomics infrastructure and equipment facility

    PEO2: to orient the students to solve the real-world problems with genomics and computational genomics technologies

    PEO3: to engage in cutting-edge research in genomics and high-throughput methods

    PEO4: to expose the students to genomic / NGS / Genome sequence analysis and related services to the needs of academics, industries, hospitals, and other service sectors, and

    PEO5: to expose and make the students learn with the industrial and start-up ecosystem, which all aiming to culminate with the orientation of students for solving the real world and research problems, development of the technologies and products for further applications and translational investigations. These would be achieved through teaching and the parallel focused research investigations in the directions of Biomedical genomics, Computational Genomics, Microbial Genomics, Plant & Animal Genomics, and High-throughput drug repurpose / microbial / metabolite screening and lead development to make a significant contribution in the area of disease diagnostics and therapeutics. 

     

    PROGRAM OUTCOMES (POs):

    PO1: With the extensive hands-on training in the program, after completing this course, students would be highly knowledgeable in Genomics and related "OMICS" subjects.

    PO2: Highly skilled human resources would be developed with the expertise in one or a few of the following areas: Human Genomics, Biomedical genomics, Computational Genomics, Microbial Genomics, Plant & Animal Genomics, and High-throughput methods.

    PO3: Students would be oriented for undertaking a research career in a leading Institution across the globe or to take a job in genomics and related industries.

    PO4: Students would be prepared to solve real-world biological and biomedical problems with genomic approaches.

    PO5: There would be a high demand for the M.Sc Genomics graduates in research institutions as well as in the industries providing genomic / NGS /  related services. After completing this course, students are readily employable in research positions in academia and industries. 

     

    PROGRAM SPECIFIC OUTCOME (PSO):

    PSO1. Students will develop a compressive knowledge of Microbial-, Plant-, and Human Genomes and the recent trends in Genomics research. Students will be able to understand the methods used in the field of Genomics, including metagenomics and human microbiomics. They can annotate genomes and metagenomes using various bioinformatics resources. Also, students will understand the basics of proteins, metabolites, and methods of Proteomics and Metabolomics. Students will be trained to analyze genomics related research papers critically. Also, they will be able to design and write research projects in genomics.  

    PSO2. Students will learn mathematical and computational methods and algorithms used to explore the biological and genomic data. Students will understand scripts and the logic of exploring, identifying, and using them for various computational analysis methods, including sequence analysis, genome analysis, and expression analysis. Students will be able to analyze the simple sequences to genome sequences as well as genome-wide data. Students will be familiarized with the basics of algorithms, work-flows and programing languages for computational biological and computational genomic investigations.

    PSO3.  Students will understand the basic microbial structure and similarities and differences among various groups of microorganisms, such as bacteria/archaea/cyanobacteria/fungi/ protozoa. Students will understand the role of microbes in infectious diseases. Also, they will learn beneficial aspects of the microorganisms such as roles in recycling soil nutrients, biodegradation of complex plant polymers, sustaining and improving plant growth through improving nutrient availability, production of plant growth-promoting substances, and inhibiting pathogens. Students will learn how to develop bioprocess technology for the commercialization of microbial products. 

    PSO4. Students will learn the basics of macromolecule structure and their functions. Students will understand the various properties of biomolecules, such as metabolic, chemical, and biological properties. Students can discover the applications of enzymes and enzyme kinetics with the knowledge on Michaelis- Menton equation and Line-Waever Burk plot. Students will learn the metabolism of carbohydrates, amino acid, lipid, nucleic acid, and their regulation.

    PSO5. Students will be acquainted with the different components and mechanisms of genetic determinants and their significance in life. Students will be familiarized with the classical experiments in molecular biology, genetics, and bacterial genetics. Students can understand transcriptional regulation, various molecular, cellular processes. Also, students will learn patterns of genetic inheritance, various genetic elements/ factors, gene/chromosomal mapping methods, the importance of mutations and mutagenesis, etc. Students can understand the genetic disorders in humans, including the fundamentals of cancer genetics.

    PSO6. Students will enlighten with the contemporary basic and functional concepts about Biodiversity and the need for conservation. It will give the students more profound insights into the marine ecosystem and the climate change impacts on the invaluable ecosystem components. To train the students to the various bio-statistics methods and application of statistical purposes to a wide range of conditions in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments, and the interpretation of the results. On the successful completion of the course, students will be able to collect, organize, and present the biological data. Also, they can analyze the data using appropriate statistical tools.

    PSO7. To introduce the basics of immunology and immune-techniques applicable in biomedical research. Students will be able to understand the mechanisms behind the functioning of the immune system in defending the infections. Students also will be exposed to all the concepts of molecular, cellular immunology, autoimmune disease, allergy, etc.. On completion of the course, the student is expected to understand how does the immune system work at the molecular and cellular levels. Also, they can identify what immunotechniques can be used in disease diagnostics.

    PSO8. To provide comprehensive knowledge on fundamental aspects of gene cloning, including the components of a variety of cloning and expression vectors used for cloning. To study the enzymes in molecular cloning, specific applications, and methods in genetic engineering. To develop the working knowledge of various cloning strategies. On completion of this course, the students will be able to plan a cloning strategy using different cloning vectors and enzymes. Also, they will be familiar with genetic engineering, recombineering, genome engineering methods.

    PSO9. To make students understand the molecular and cellular architecture and functional processes of various tissues, cell types, organelles, and cellular / extra-cellular components. Also, to understand the molecular and cellular features of stem cells and developmental biological processes. To get better insights into the molecular, cellular structure and biology of the cellular organelles and components and the cellular processes including cell division, transports, migration, and oncogenesis processes.

    PSO10. Students will develop skills in research in genomics laboratories and good laboratory practices, antibiotic discovery research, and innovative high throughput screening strategies in antibiotic research. Students also may identify novel antibiotics and novel microorganisms. Students will develop expertise in drug discovery and development and readily employable in research labs and pharma industry. Also, to facilitate networking skills with international researchers and students.